Foye's Principles of Medicinal Chemistry 7th Edition by David A. Williams offers updated chapters plus new material that meets the needs of today's medicinal chemistry courses. This latest edition offers an unparalleled presentation of drug discovery and pharmacodynamic agents, integrating principles of medicinal chemistry with pharmacology, pharmacokinetics, and clinical pharmacy.
This text has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. Emphasis is on patient-focused pharmaceutical care and on the pharmacist as a therapeutic consultant, rather than a chemist.
A new disease state management section explains appropriate therapeutic options for asthma, chronic obstructive pulmonary disease, and men's and women's health problems. Also new to this edition: Clinical Significance boxes, Drug Lists at the beginning of appropriate chapters, and an eight-page color insert with detailed illustrations of drug structures. Case studies from previous editions and answers to this edition's case studies are available online at the Point.
All the chapters have been written by an international team of respected researchers and academicians. Careful editing ensures thoroughness, a consistent style and format, and easy navigation throughout the text. This is still the gold standard against which all other medicinal chemistry books must be judged. It is content rich, yet attempts to relate the discipline to modern clinical practice. It is comprehensive and accessible, and an excellent resource for students as well as professionals seeking to update their knowledge.
The addition of the clinical significance sections alone justifies replacing the previous edition. Following an introduction to drug discovery and its relation to absorption, metabolism, and physiochemical and biopharmaceutical properties of drugs, each of the book's subsequent three parts addresses particular drug classes.
The division of subjects is rational and informative. Of particular note is the last section on disease state management with particularly unique coverage of women's and men's health. It is here that students can see the clinical application of a diverse group, such as gonadal steroids. The clinical vignettes and clinical significance explanations throughout the book are unique and important. The book's main shortcoming (not for me, however), as with many detailed tomes, is its sheer size.
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